Magic Touch Peripheral Drug Coated Sirolimus Balloon

SIROLIMUS COATED BALLOON :
AN EXCELLENT ALTERNATIVE FOR REVASCULAZATION OF SFA AND BTK ARTERIES

MagicTouch PTA is intended to prevent re-narrowing of superficial femoral and popliteal arteries in patients with peripheral artery disease.

Assuring Safety by Delivering Sirolimus

  • TECHNOLOGY - MagicTouch PTA

    TECHNOLOGY

    An innovative proprietary Nanolute technology providing better bioavailability of SIROLIMUS

  • COATING - MagicTouch PTA

    COATING

    Unique coating technology leads to 100% balloon surface coating

  • DRUG - MagicTouch PTA

    DRUG

    Sirolimus: A drug with proven safety profile

  • Unique Coating Technology

    Drug carrier along with drug is coated on the unfolded balloon to achieve 100% coating on balloon surface
    Unique and proprietary refolding mechanism facilitates better crossing profile

    Nanolute Technology

    NANOLUTE TECHNOLOGY is designed to improve the lipophilicity and bioavailability of Sirolimus

    • Phospholipid is a drug carrier with two lipophilic tails and one hydrophilic head.
    • Sirolimus is encapsulated in phospholipid with proprietary Nanolute technology.

    • Conversion of Sirolimus drug into sub-micron sized particles
    • Nanocarriers created by encapsulation of sub-micron sized
      Sirolimus drug into highly biocompatible drug
      Carrier-phospholipid
    • Upon inflation of MagicTouch SCB at target site, nanocarriers
      with Sirolimus drug inside gets transferred to the vessel wall
      following the principle of co-efficient diffusion
    • Upon body pH variation, nanocarriers mimics the body lipids and
      liberates Sirolimus
    • The sub-micron sized Sirolimus drug particles penetrate the
      deepest layer of the vessel over a period

    Challenges Addressed by Nanolute Technology

    Improves Lipophilicity of Sirolimus

    • Lipophilicity is the ability of a drug to dissolve in fats, oils, lipids.
    • Sirolimus possess poor lipophilicity and hence require phospholipid.
    • NANOLUTE technology delivers polymer-free nanocarriers containing sirolimus surrounded by encapsulation of a
      proprietary drug carrier, i.e., a phospholipid and improves lipophilicity.

    Enhanced Bioavailibility of Sirolimus

    • Bioavailability is a measure of the amount of a drug that reaches the target site.
    • The bioavailability of sirolimus is poor due to higher wash-out rate in the blood stream.
    • The coating of nanocarriers provides very low in-transit drug loss and better drug diffusion, as well as drug retention
      throughout the artery, and penetration of sirolimus to the deep layers of the coronary artery results in enhanced
      bioavailability.

    Advantages of Nanolute Technology

    • Facilitates better adhesion of Sirolimus on the balloon surface

      Facilitates better adhesion of Sirolimus on the balloon surface

    • Effective drug transfer to the deepest layer of the vessel

      Effective drug transfer to the deepest layer of the vessel

    • Circumferential coating

      Circumferential coating

    • Better in-tissue bioavailability of Sirolimus

      Better in-tissue bioavailability of Sirolimus

     Sirolimus Distribution Study

    DTF labelled Sirolimus was used to study the drug distribution following DCB treatment*

    ONE HOUR

    DAY THREE

    DAY SEVEN

    A: Adventitia; EEL: External Elastic Lamina; IEL: Internal Elastic Lamina; L:Lumen; M: Media *EuroIntervention. 2013 May 20;9(1): 148-56

    Balloon Catheter

    MagicTouch PTA
    MagicTouch PTA

    TECHNICAL SPECIFICATION

    Guidewire compatibility” Balloon Diameter(mm)
    0.035” 3.00, 4.00 5.00, 6.00, 7.00, 8.00, 9.00, 10.00, 12.00
    0.018” 2.00, 2.50, 3.00, 3.50, 4.00, 4.50, 5.00, 5.50, 6.00, 7,00
    0.014” 1.50, 2.00, 2.50, 3.00, 3.50, 4.00
    Guidewire compatibility” Balloon Length (mm)
    0.035” 20, 40, 60, 80, 100, 120, 150 and 200
    0.018” 40, 60, 80, 100, 120, 150 and 200
    0.014” 20, 40, 60, 80, 100, 120, 150 and 200
    Guidewire compatibility” Catheter Shaft Length(cm)
    0.035” 45, 80, 90, 130, 150
    0.018” 90, 120, 150
    0.014” 90, 120, 150
    Drug/Excipient
    Drug Sirolimus
    Drug Dose 1.27 µg/mm2
    Drug Carrier Phospholipid
    Balloon
    Delivery System Over The Wire
    Balloon Folding 3 folds & 6 Folds
    Balloon Compliance Semi-Compliant
    Sheath Compatibility 5F to 8F
    Guiding Catheter Compatibility 6F to 9F
    Shelf life 2-years

    ORDERING INFORMATION

    Magic Touch PTA 0.014″ OTW

    Length (mm) (Shaft Length= 90cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPTW14026 CPTW14027 CPTW14028 CPTW14029 CPTW14030 CPTW14031 CPTW14032
    2.50 CPTW14033 CPTW14034 CPTW14035 CPTW14036 CPTW14037 CPTW14038 CPTW14039
    3.00 CPTW14040 CPTW14041 CPTW14042 CPTW14043 CPTW14044 CPTW14045 CPTW14046
    3.50 CPTW14047 CPTW14048 CPTW14049 CPTW14050 CPTW14051 CPTW14052 CPTW14053
    4.00 CPTW14054 CPTW14055 CPTW14056 CPTW14057 CPTW14058 CPTW14059 CPTW14060

     

    Length (mm) (Shaft Length= 120cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPT14200040 CPT14200060 CPT14200080 CPT14200100 CPT14200120 CPT14200150 CPT14200200
    2.50 CPT14250040 CPT14250060 CPT14250080 CPT14250100 CPT14250120 CPT14250150 CPT14250200
    3.00 CPT14300040 CPT14300060 CPT14300080 CPT14300100 CPT14300120 CPT14300150 CPT14300200
    3.50 CPT14350040 CPT14350060 CPT14350080 CPT14350100 CPT14350120 CPT14350150 CPT14350200
    4.00 CPT14400040 CPT14400060 CPT14400080 CPT14400100 CPT14400120 CPT14400150 CPT14400200

     

    Length (mm) (Shaft Length= 150cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPTW14062 CPTW14063 CPTW14064 CPTW14065 CPTW14066 CPTW14067 CPTW14068
    2.50 CPTW14069 CPTW14070 CPTW14071 CPTW14072 CPTW14073 CPTW14074 CPTW14075
    3.00 CPTW14076 CPTW14077 CPTW14078 CPTW14079 CPTW14080 CPTW14081 CPTW14082
    3.50 CPTW14083 CPTW14084 CPTW14085 CPTW14086 CPTW14087 CPTW14088 CPTW14089
    4.00 CPTW14090 CPTW14091 CPTW14092 CPTW14093 CPTW14094 CPTW14095 CPTW14096

    Magic Touch PTA 0.018″ OTW

    Length (mm) (Shaft Length= 90cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPTW18099 CPTW18100 CPTW18101 CPTW18102 CPTW18103 CPTW18104 CPTW18105
    2.50 CPTW18106 CPTW18107 CPTW18108 CPTW18109 CPTW18110 CPTW18111 CPTW18112
    3.00 CPTW18113 CPTW18114 CPTW18115 CPTW18116 CPTW18117 CPTW18118 CPTW18119
    3.50 CPTW18120 CPTW18121 CPTW18122 CPTW18123 CPTW18124 CPTW18125 CPTW18126
    4.00 CPTW18127 CPTW18128 CPTW18129 CPTW18130 CPTW18131 CPTW18132 CPTW18133
    5.00 CPTW18134 CPTW18135 CPTW18136 CPTW18137 CPTW18138 CPTW18139 CPTW18140
    5.50 CPTW18141 CPTW18142 CPTW18143 CPTW18144 CPTW18145 CPTW18146 CPTW18147
    6.00 CPTW18148 CPTW18149 CPTW18150 CPTW18151 CPTW18152 CPTW18153 CPTW18154

     

    Length (mm) (Shaft Length= 120cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPT18200040 CPT18200060 CPT18200080 CPT18200100 CPT18200120 CPT18200150 CPT18200200
    2.50 CPT18250040 CPT18250060 CPT18250080 CPT18250100 CPT18250120 CPT18250150 CPT18250200
    3.00 CPT18300040 CPT18300060 CPT18300080 CPT18300100 CPT18300120 CPT18300150 CPT18300200
    3.50 CPT18350040 CPT18350060 CPT18350080 CPT18350100 CPT18350120 CPT18350150 CPT18350200
    4.00 CPT18400040 CPT18400060 CPT18400080 CPT18400100 CPT18400120 CPT18400150 CPT18400200
    5.00 CPT18500040 CPT18500060 CPT18500080 CPT18500100 CPT18500120 CPT18500150 CPT18500200
    5.50 CPT18550040 CPT18550060 CPT18550080 CPT18550100 CPT18550120 CPT18550150 CPT18550200
    6.00 CPT18600040 CPT18600060 CPT18600080 CPT18600100 CPT18600120 CPT18600150 CPT18600200

     

    Length (mm) (Shaft Length= 150cm)
    Diameter (mm) 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    2.00 CPTW18156 CPTW18157 CPTW18158 CPTW18159 CPTW18160 CPTW18161 CPTW18162
    2.50 CPTW18163 CPTW18164 CPTW18165 CPTW18166 CPTW18167 CPTW18168 CPTW18169
    3.00 CPTW18170 CPTW18171 CPTW18172 CPTW18173 CPTW18174 CPTW18175 CPTW18176
    3.50 CPTW18177 CPTW18178 CPTW18179 CPTW18180 CPTW18181 CPTW18182 CPTW18183
    4.00 CPTW18184 CPTW18185 CPTW18186 CPTW18187 CPTW18188 CPTW18189 CPTW18190
    5.00 CPTW18191 CPTW18192 CPTW18193 CPTW18194 CPTW18195 CPTW18196 CPTW18197
    5.50 CPTW18198 CPTW18199 CPTW18200 CPTW18201 CPTW18202 CPTW18203 CPTW18204
    6.00 CPTW18205 CPTW18206 CPTW18207 CPTW18208 CPTW18209 CPTW18210 CPTW18211

    Magic Touch PTA 0.035″ OTW

    Length (mm) (Shaft Length= 45cm= 450 mm)
    Diameter (mm) 20.00 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    3.00 CPTW35113 CPTW35114 CPTW35115 CPTW35116
    4.00 CPTW35117 CPTW35118 CPTW35119 CPTW35120 CPTW35121 CPTW35122
    5.00 CPTW35123 CPTW35124 CPTW35125 CPTW35126 CPTW35127 CPTW35128
    6.00 CPTW35129 CPTW35130 CPTW35131 CPTW35132 CPTW35133 CPTW35134
    7.00 CPTW35135 CPTW35136 CPTW35137 CPTW35138 CPTW35139
    8.00 CPTW35140 CPTW35141 CPTW35142 CPTW35143 CPTW35144
    9.00 CPTW35145 CPTW35146 CPTW35147 CPTW35148
    10.00 CPTW35149 CPTW35150 CPTW35151 CPTW35152

     

    Length (mm) (Shaft Length= 80cm = 800 mm)
    Diameter (mm) 20.00 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    3.00 CPTW35001 CPTW35002 CPTW35003 CPTW35004
    4.00 CPTW35005 CPTW35006 CPTW35007 CPTW35008 CPTW35009 CPTW35010 CPTW35011 CPTW35012
    5.00 CPTW35013 CPTW35014 CPTW35015 CPTW35016 CPTW35017 CPTW35018 CPTW35019 CPTW35020
    6.00 CPTW35021 CPTW35022 CPTW35023 CPTW35024 CPTW35025 CPTW35026 CPTW35027 CPTW35028
    7.00 CPTW35029 CPTW35030 CPTW35031 CPTW35032 CPTW35033 CPTW35034 CPTW35035 CPTW35036
    8.00 CPTW35037 CPTW35038 CPTW35039 CPTW35040 CPTW35041 CPTW35042 CPTW35043 CPTW35044
    9.00 CPTW35045 CPTW35046 CPTW35047 CPTW35048
    10.00 CPTW35049 CPTW35050 CPTW35051 CPTW35052
    12.00 CPTW35053 CPTW35054 CPTW35055 CPTW35056

     

    Length (mm) (Shaft Length= 90cm = 900 mm)
    Diameter (mm) 20.00 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    3.00 CPTW35057 CPTW35058 CPTW35059 CPTW35060
    4.00 CPTW35061 CPTW35062 CPTW35063 CPTW35064 CPTW35065 CPTW35066 CPTW35067 CPTW35068
    5.00 CPTW35069 CPTW35070 CPTW35071 CPTW35072 CPTW35073 CPTW35074 CPTW35075 CPTW35076
    6.00 CPTW35077 CPTW35078 CPTW35079 CPTW35080 CPTW35081 CPTW35082 CPTW35083 CPTW35084
    7.00 CPTW35085 CPTW35086 CPTW35087 CPTW35088 CPTW35089 CPTW35090 CPTW35091 CPTW35092
    8.00 CPTW35093 CPTW35094 CPTW35095 CPTW35096 CPTW35097 CPTW35098 CPTW35099 CPTW35100
    9.00 CPTW35101 CPTW35102 CPTW35103 CPTW35104
    10.00 CPTW35105 CPTW35106 CPTW35107 CPTW35108
    12.00 CPTW35109 CPTW35110 CPTW35111 CPTW35112

     

    Length (mm) (Shaft Length= 130cm=1300 mm)
    Diameter (mm) 20.00 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    3.00 CPTW35153 CPTW35154 CPTW35155 CPTW35156
    4.00 CPTW35157 CPTW35158 CPTW35159 CPTW35160 CPTW35161 CPTW35162 CPTW35163 CPTW35164
    5.00 CPTW35165 CPTW35166 CPTW35167 CPTW35168 CPTW35169 CPTW35170 CPTW35171 CPTW35172
    6.00 CPTW35173 CPTW35174 CPTW35175 CPTW35176 CPTW35177 CPTW35178 CPTW35179 CPTW35180
    7.00 CPTW35181 CPTW35182 CPTW35183 CPTW35184 CPTW35185 CPTW35186 CPTW35187 CPTW35188
    8.00 CPTW35189 CPTW35190 CPTW35191 CPTW35192 CPTW35193 CPTW35194 CPTW35195 CPTW35196
    9.00 CPTW35197 CPTW35198 CPTW35199 CPTW35200
    10.00 CPTW35201 CPTW35202 CPTW35203 CPTW35204
    12.00 CPTW35205 CPTW35206 CPTW35207 CPTW35208

     

    Length (mm) (Shaft Length= 150 cm=1500 mm)
    Diameter (mm) 20.00 40.00 60.00 80.00 100.00 120.00 150.00 200.00
    3.00 CPTW35209 CPTW35210 CPTW35211 CPTW35212
    4.00 CPTW35213 CPTW35214 CPTW35215 CPTW35216 CPTW35217 CPTW35218 CPTW35219 CPTW35220
    5.00 CPTW35221 CPTW35222 CPTW35223 CPTW35224 CPTW35225 CPTW35226 CPTW35227 CPTW35228
    6.00 CPTW35229 CPTW35230 CPTW35231 CPTW35232 CPTW35233 CPTW35234 CPTW35235 CPTW35236
    7.00 CPTW35237 CPTW35238 CPTW35239 CPTW35240 CPTW35241 CPTW35242 CPTW35243 CPTW35244
    8.00 CPTW35245 CPTW35246 CPTW35247 CPTW35248 CPTW35249 CPTW35250 CPTW35251 CPTW35252
    9.00 CPTW35253 CPTW35254 CPTW35255 CPTW35256
    10.00 CPTW35257 CPTW35258 CPTW35259 CPTW35260
    12.00 CPTW35261 CPTW35262 CPTW35263 CPTW35264

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